Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma

Hodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma

  Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...

Advanced-stage nodular lymphocyte predominant Hodgkin lymphoma compared with classical Hodgkin lymphoma: a matched pair outcome analysis.

Due to disease rarity, there is limited information regarding the optimal therapy and outcome for patients with advanced-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Forty-two patients with NLPHL by the Revised European-American Lymphoma/World Health Organization classification with advanced-stage disease were identified and paired 1:2 with a matched control with classical Hod...

Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells.

A 15-year-old young man presented to the emergency department with a 3-week history of sharp left-sided chest pain, shortness of breath on exertion, and a low-grade intermittent fever. Chest radiograph revealed increased density in the upper left lobe, thus he was treated with antibiotics for query pneumonia. Although his fever subsided, the patient continued to have chest pain, and subsequentl...

Granulomatous bone marrow involvement of Hodgkin lymphoma, nodular sclerosis type

GWAS Analysis of Young Adult Nodular Sclerosis Hodgkin Lymphoma

Rationale General Background NSHL is the most common subtype of Hodgkin lymphoma in young adults, comprising between 60-80% of the disease in this age group; it occurs equally in males and females, peaks in incidence in the early 20’s, and is associated with higher socioeconomic status and low prevalence of Epstein-Barr virus in the tumors (1,2). Although commonly classified together with the m...